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How can CBD help my cats anxiety? Boosting active levels of gamma-Aminobutyric acid (GABA), a neurotransmitter which has a calming effect on the brain, can help, as can interacting with the 5-HT1A receptor in the serotonin system (once activated, this receptor can aide in reducing anxiety). Antidepressants are prescribed to humans to treat anxiety, but are somewhat unpopular because they are very slow to take effect. In contrast, CBD can trigger an anxiety-reducing effect at the 5-HT1A receptor (which is a type of serotonin (which is known as “the happy chemical”) receptor in the nervous system whose activation is linked